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. 2014 Aug 11;9(8):e104603. doi: 10.1371/journal.pone.0104603

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© 2014 Nishizuka et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Histologic cross sections of specimens from the IM-BM group (PLLA + CPC + PHA) stained with hematoxylin and eosin. (a) A PHA fiber mat layer surrounded the CPC, and the PLLA tube was not degraded at week 20. (b) At week 52, the PLLA tube seemed to have degraded gradually. (c) Multinucleated giant cell (arrowhead) and neovascularization were observed in the PHA fiber mat layer at week 52. PHA fiber (arrow). PL: PLLA woven tube; PH: PHA fiber mat C: CPC; B: bone cortex; BM: bone marrow.