Table 3. Immune cell regulation GO cluster genes.
| GeneName | Gene Accession Number | Description | Number ofDifferentiallyMethylatedCpGs | Genic Region | Methylationstatus (CFS-CTL) |
| ATG7 | NM_001136031/NM_001144912/NM_006395 | ATG7 autophagy related 7homolog (S. cerevisiae) | 1 | TSS1500 | hypermethylated |
| BCL10 | NM_003921 | B-cell CLL/lymphoma 10 | 1 | TSS200 | hypermethylated |
| CD83 | NM_001040280/NM_004233 | CD83 molecule | 1 | 3′ UTR | hypermethylated |
| FCER2 | NM_002002 | Fc fragment of IgE, low affinity II,receptor for (CD23) | 1 | TSS1500 | hypermethylated |
| HLA-H | NR_001434 | major histocompatibility complex,class I, H (pseudogene) | 1 | TSS200 | hypermethylated |
| IL19 | NM_153758 | interleukin 19 | 1 | TSS1500 | hypermethylated |
| IL1RL1 | NM_016232 | interleukin 1 receptor-like 1 | 1 | TSS1500 | hypermethylated |
| LAIR1 | NM_002287/NM_021706 | leukocyte-associatedimmunoglobulin-like receptor 1 | 1 | TSS1500 | hypermethylated |
| TNFSF13B | NM_001145645/NM_006573 | tumor necrosis factor (ligand)superfamily, member 13b | 1 | TSS1500 | hypermethylated |
| TREM2 | NM_018965 | triggering receptor expressedon myeloid cells 2 | 1 | TSS200 | hypermethylated |
| CD3D | NM_000732/NM_001040651 | CD3d molecule, delta(CD3-TCR complex) | 4 | TSS1500 | hypomethylated |
| CD3E | NM_000733 | CD3e molecule, epsilon(CD3-TCR complex) | 1 | 5′ UTR | hypomethylated |
| CD3G | NM_000073 | CD3g molecule, gamma(CD3-TCR complex) | 4 | 5′ UTR/1st Exon | hypomethylated |
| CD96 | NM_005816/NM_198196 | CD96 molecule | 1 | TSS200 | hypomethylated |
| FASLG | NM_000639 | Fas ligand (TNF superfamily,member 6) | 1 | TSS200 | hypomethylated |
| HLA-E | NM_005516 | major histocompatibilitycomplex, class I, E | 2 | 3′ UTR | hypomethylated |
| ICOS | NM_012092 | inducible T-cell co-stimulator | 1 | 5′ UTR/1st Exon | hypomethylated |
| LAX1 | NM_001136190/NM_017773 | lymphocyte transmembraneadaptor 1 | 2 | 5′ UTR/1st Exon | hypomethylated |
| LCK | NM_005356 | lymphocyte-specificprotein tyrosine kinase | 2 | 5′ UTR | hypomethylated |
| LY9 | NM_001033667/NM_002348 | lymphocyte antigen 9 | 1 | TSS200 | hypomethylated |
Examples of genes within the immune cell regulation cluster differentially methylated at gene regulatory elements in CFS patients compared to healthy control subjects.