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. 2014 Aug 11;9(8):e104802. doi: 10.1371/journal.pone.0104802

Figure 2. A dramatic and lasting switch in salt preference after 24 h one-bottle tests with IS and HS solutions.

Figure 2

Ai, Mean fluid intake following 5 different 24 h one-bottle treatments, control, IS, HS, DH and 4% HSD. Aii, water intake measures for the proceeding 24 h after treatment. B, mean intakes of water and IS solution in two-bottle choice tests performed 7 d after one-bottle tests. C, mean salt preference scores for all groups calculated from the total fluid intake data in B. D, the two-bottle choice tests were repeated 35 d after one-bottle tests for control WEx, ISEx and HSEx groups. Values are means +SEM of n = 6–10 animals per group. E, mean salt preference scores for all groups calculated from the total fluid intake data in D. *p<0.05, **p<0.01, ***p<0.001. DH, dehydrated; HS, hypertonic saline; HSD, high salt diet; HSEx, hypertonic saline exposed; IS, isotonic saline ISEx isotonic saline exposed; W, water; WEx, water exposed.