Figure 1. NOS activity measured as pmol [14C] L-citrulline/g tissue/min.

Two-way ANOVA showed no statistically significant interaction between the effects of Diabetes and L-Arg treatment on NOS activity. The effects of Diabetes and L-Arg were considered extremely significant (p<0.001). ***p<0.001 vs. control untreated rats; ###p<0.001 vs. control rats treated with L-Arg; &&&p<0.001 vs. diabetic untreated rats. Data are mean ± SEM (n = 8).