Table 1. Summary of some general and renal parameters in control and diabetic rats.
| C | D | C+A | D+A | |
| Initial body weight (g) | 307.3±11.1 | 320.6±21.7 | 311.2±12.0 | 327.2±20.5 |
| Final body Weight (g) | 355.1±17.2 | 270.1±19.4*** | 347.9±22.5 | 275.6±16.1### |
| Kidney weight/body weight (mg/g) | 3.7±0.2 | 5.4±0.4** | 4.2±0.4 | 5.1±0.5## |
| Blood glucose (mmol/l) | 5.6±0.5 | 16.1±1.7*** | 5.0±0.4 | 15.7±1.2### |
| Urinary volume (ml/24 h) | 10.3±1.1 | 15.9±1.4* | 9.0±1.2 | 12.9±1.4# |
| Osmolar excretion rate (mOsm/24 h) | 8.5±1.1 | 18.2±2.5** | 9.5±1.6 | 16.3±3.2## |
| Urinary glucose (mmol/l) | Undetectable (0.00±0.00) | 33.3±9.4*** | Undetectable (0.00±0.00) | 30.5±9.1### |
| Urinary ketones (mmol/l) | Undetectable (0.00±0.00) | 0.78±0.19*** | Undetectable (0.00±0.00) | 0.29±0.12### |
| Urinary proteins (mg/24 h) | 6.4±0.4 | 6.9±1.6 | 6.7±0.3 | 4.7±0.5 |
| Creatinine clearance (ml/min) | 1.09±0.15 | 1.33±0.12 | 0.93±0.11 | 1.12±0.14 |
| NOx (nmol/mg creatinine) | 10.6±1.3 | 5.0±0.6* | 11.8±0.7 | 13.9±2.4&&& |
C: control rats; D: diabetic untreated rats; D+A: diabetic rats treated with L-Arg; C+A: control rats treated with L-Arg. Results are expressed as the mean ± SEM (n = 6).
Two-way ANOVA showed a statistically significant interaction (p<0.05) between the effects of Diabetes and L-Arg treatment on NOx urinary excretion. There was no interaction between the effects of Diabetes and L-Arg treatment on the other parameters. Diabetes had a significant overall effect on Final body weight (p<0.001), Kidney weight/body weight (p<0.001), Blood glucose (p<0.001), Urinary volume (p<0.05), Osmolar excretion rate (p<0.01), Urinary glucose (p<0.001) and Urinary ketones (p<0.001). L-Arg had no significant effect on any of the parameters tested. *p<0.05 vs. C; **p<0.01 vs. C; ***p<0.001 vs. C; #p<0.05 vs. C+A; ##p<0.01 vs. C+A ###p<0.001 vs. C+A; &&&p<0.001 vs. D.