Table 1. Comparison of Demographics, Time Interval, and Outcome Variables Between the Pre-Stroke Code and Stroke Code Eras.
| Pre-Stroke Code era (n = 91) | Stroke Code era (n = 216) | P value | |
| Age, years | 68.6±12.0 | 67.6±12.7 | 0.497 |
| Male | 59 (64.8) | 122 (56.5) | 0.174 |
| Stroke risk factors | |||
| Hypertension | 67 (73.6) | 159 (73.6) | 0.998 |
| Diabetes mellitus | 28 (30.8) | 71 (32.9) | 0.719 |
| Dyslipidemia | 22 (24.2) | 85 (39.5) | 0.010 |
| Atrial fibrillation | 55 (60.4) | 100 (46.3) | 0.024 |
| Coronary artery disease | 14 (15.4) | 40 (18.5) | 0.510 |
| Prior stroke | 15 (16.5) | 48 (22.2) | 0.256 |
| Smoking | 20 (22.0) | 53 (24.5) | 0.631 |
| Initial NIHSS (IQR) | 15 (10–21) | 12 (7–17) | <0.001 |
| Stroke subtype | |||
| Cardioembolism | 54 (59.3) | 105 (48.6) | 0.324 |
| Large-artery atherosclerosis | 20 (22.0) | 52 (24.1) | |
| Small-vessel occlusion | 5 (5.5) | 18 (8.3) | |
| Others | 12 (13.2) | 41 (19.0) | |
| Arrival during working hours | 39 (42.9) | 72 (33.3) | 0.113 |
| Time interval, min (IQR) | |||
| Onset-to-door | 45 (30–65) | 58 (32–94.5) | 0.009 |
| Door-to-CT | 24 (19–38.5) | 11 (9–13) | <0.001 |
| Door-to-INR | 60 (49–119) | 43 (37–52.3) | <0.001 |
| CT-to-needle | 61 (44–79) | 40 (32–51) | <0.001 |
| Door-to-needle | 88 (67–107) | 51 (43–64) | <0.001 |
| Onset-to-needle | 145 (122–163) | 125 (90.3–157) | <0.001 |
| Door-to-CT ≤25 minutes | 48 (52.7) | 198 (91.7) | <0.001 |
| Door-to-needle ≤60 minutes | 13 (14.3) | 154 (71.3) | <0.001 |
| Onset-to-needle 3–4.5 hours | 7 (7.7) | 23 (10.6) | 0.426 |
| Outcome | |||
| Symptomatic ICH | 7 (7.7) | 10 (4.6) | 0.285 |
| Good outcome at discharge | 36 (39.6) | 107 (49.5) | 0.110 |
| Good outcome at 3 months | 40 (44.0) | 109 (50.5) | 0.298 |
| In-hospital mortality | 6 (6.6) | 7 (3.2) | 0.216 |
CT, computed tomography; ED, emergency department; EMS, emergency medical service; ICH, intracranial hemorrhage; INR, international normalized ratio; IQR, interquartile range.