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General route for synthesis of triazolyl berberine derivatives.
Notes: Reagents and conditions: (A) 190°C, 20–30 mmHg, 15 minutes; (B) BrCH2C≡CH, CH3CN, reflux, 2.5 hours; (C) DMF, 3 hours; (D) CuSO4 · 5H2O, sodium ascorbate, DMF, 50°C.
Abbreviation: DMF, dimethylformamide.
