Figure 4.

(A) Tumor inhibition effects of different DOX formulations. The drug doses were 5.0 mg/kg for DOX solution and (NH₄)₂SO₄-L, and 2.5, 5.0, 10.0 mg/kg for the low, middle, and high concentration of NH₄EDTA-L, respectively. (B) Damage of different formulations on immune organs of H₂₂-bearing mice.

Notes: The data represent mean ± standard deviation. *P<0.05 versus NS-treated mice; **P<0.01 versus NS-treated mice; ^#P<0.05 versus DOX solution-treated mice.

Abbreviations: DOX, doxorubicin; EDTA, ethylenediaminetetraacetic acid; L, doxorubicin-loaded liposomes; NS, normal saline.