Figure 6.

Typical images of pathological classification of myocardium injury of different DOX formulations: (A) NS; (B) DOX solution; (C) NH₄EDTA-L (low-dose); (D) NH₄EDTA-L (medium-dose); (E) NH₄EDTA-L (high-dose); and (F) (NH₄)₂SO₄-L.

Notes: Photographs were obtained under a fluorescence microscope (IX71; Olympus Corporation, Tokyo, Japan) using a 40× objective. The black circles point out the damaged sites of myocardium fragmentation.

Abbreviations: DOX, doxorubicin; EDTA, ethylenediaminetetraacetic acid; L, doxorubicin-loaded liposomes; NS, normal saline.