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The effect of macrophage depletion in the tolerant rats on the pharmacokinetics and biodistribution of PE.
Notes: (A) Blood clearance. (B) Hepatic and splenic accumulation 12 hours after intravenous injection of the test dose. Data are shown as mean ± SD, n=3; ***P<0.001.
Abbreviations: AD-L, liposomes containing alendronate; PE, PEGylated emulsion; PEG, polyethylene glycol; SD, standard deviation.
