Table 1.
Weekly injectionsb | AUC ratio | Daily injectionsc | AUC ratio |
---|---|---|---|
PE-2 | 0.10±0.06***,d | 7 d-PE | 0.10±0.01*** |
PE-3 | 0.32±0.09*** | 11 d-PE | 0.21±0.08*** |
PE-4 | 0.45±0.09** | 14 d-PE | 0.21±0.05*** |
PE-5 | 1.37±0.08* | 17 d-PE | 0.50±0.18** |
PE-6 | 1.39±0.09* | 21 d-PE | 1.37±0.11* |
PE-7 | 1.46±0.28* |
Notes:
The AUC ratio was calculated as follows: AUC ratio = AUC(0–12 h) of the treated group/AUC(0–12 h) of the control group
PE-n represents the nth-week PE injection
n d-PE represents the nth-day PE injection
P-values apply to differences between the treated groups and 1
P<0.05
P<0.01
P<0.001.
Abbreviations: AUC, area under the blood concentration–time curve; PE, PEGylated emulsion; PEG, polyethylene glycol.