Table 1.

The AUC ratio^a of weekly administrations and daily injections of PE

Weekly injectionsb	AUC ratio	Daily injectionsc	AUC ratio
PE-2	0.10±0.06***,d	7 d-PE	0.10±0.01***
PE-3	0.32±0.09***	11 d-PE	0.21±0.08***
PE-4	0.45±0.09**	14 d-PE	0.21±0.05***
PE-5	1.37±0.08*	17 d-PE	0.50±0.18**
PE-6	1.39±0.09*	21 d-PE	1.37±0.11*
PE-7	1.46±0.28*

Notes:

^aThe AUC ratio was calculated as follows: AUC ratio = AUC_{(0–12 h)} of the treated group/AUC_{(0–12 h)} of the control group

^bPE-n represents the nth-week PE injection

^cn d-PE represents the nth-day PE injection

^dP-values apply to differences between the treated groups and 1

^*P<0.05

^**P<0.01

^***P<0.001.

Abbreviations: AUC, area under the blood concentration–time curve; PE, PEGylated emulsion; PEG, polyethylene glycol.