Table 1.

Basic pharmacologic characteristics of glycoprotein IIb/IIIa inhibitors

Characteristic	Eptifibatide	Abciximab	Tirofiban
Type	Synthetic cyclic heptapeptide	Fab fragment of chimeric human-murine monoclonal antibody	Synthetic nonpeptide
Molecular weight	Small molecule (832 Da)	Large molecule (47,515 Da)	Small molecule (496 Da)
Plasma half-life	2.5–2.8 hours	10–30 minutes	1.2–2 hours
Receptor binding	Seconds	Minutes	Seconds
Elimination route	Renal ~50%	Spleen	Renal 65% Biliary 25%