Figure 4. QKI inhibits tumor formation and pulmonary metastasis in nude mice. (A) Tumor incidence in mouse xenografts injected with the indicated number of LV-miQKI, LV-QKI5, LV-QKI6, or Tca8113 cells after 6 wk is shown. (B) Representative subcutaneous tumors from mice injected with 1 × 106 cells after 6 wk of transplantation are shown. (C) Tumor volumes from each group (n = 6) were also measured. **P < 0.01 vs control. (D) Representative lung tissue sections of nude mice killed at 6 wk from each group are shown (H&E; original magnification 100×). (E) The number of lung metastatic foci in each group (n = 3) was calculated. Results display the mean ± SD. *P < 0.05, **P < 0.01 vs control.