Figure 1. SCI alters expression of M1 (classical)/M2 (alternative) microglia genes in the hippocampus. (A) The mRNA levels of M1 type genes (TNFα, iNOS, IL6) were significantly increased in SCI rats at 7 d or 9 wk post-injury. (B) SCI induced M2a gene YM1 expression transiently at day 1, whereas Arg-1 elevation at 9 wk post-injury. (C) Anti-inflammatory cytokine IL10 was found no significantly changes at all-time points. *P < 0.05, **P < 0.01 vs. sham group. n = 4 (Sham), 6 (d1 SCI), 6 (d7 SCI), 5 (9 wk SCI).