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. Author manuscript; available in PMC: 2015 Jan 10.
Published in final edited form as: J Control Release. 2013 Oct 12;173:67–74. doi: 10.1016/j.jconrel.2013.10.007

Figure 4.

Figure 4

Penetration of high molecular weight HA into porcine skin is SPACE peptide concentration and pH dependent. (a) SPACE peptide concentration dependent penetration and (b) pH dependent penetration. All formulations contain 1 mg/mL HA. (a) PBS: PBS (pH 4.0, 50 mM) solution; 2 mg/mL SPACE: The SPACE-ethosomal system formulation with SPACE peptide conjugated phospholipids (2 mg/mL) at pH 4.0; 5 mg/mL SPACE: The SPACE-ethosomal system formulation with SPACE peptide conjugated phospholipids (5 mg/mL) at pH 4.0; 10 mg/mL SPACE: The SPACE-ethosomal system formulation with SPACE peptide conjugated phospholipids (10 mg/mL) at pH 4.0. (b) PBS pH 4: PBS (pH 4.0, 50 mM) solution (1 mg/mL); PBS pH 8: PBS (pH 8.0, 50 mM) solution; SES pH4: The SPACE-ethosomal system formulation with SPACE peptide conjugated phospholipids (5 mg/mL) at pH 4.0; SES pH8: The SPACE-ethosomal system formulation with SPACE peptide conjugated phospholipids (5 mg/mL) at pH 8.0. Values represent mean ± SD (n=3) *Statistically different from all other groups (p < 0.05). **Statistically very different from all other groups (p< 0.01).