Figure 2.

IL-1β induces ER stress and increases Ca²⁺ release from the ER in AR42J cells. AR42J cells were treated with or without IL-1β. The ER stress markers GRP78 (A) and IRE1α (B) expression levels were quantified by western blot analysis. Representative trace shows the effect of IL-1β on inducing [Ca²⁺] oscillation (C). The data were obtained from at least 5 separate experiments. Representative trace shows the effect of 2APB on IL-1β induced Ca²⁺ release (D).