Silencing of PNMA1 reduces activation of p-Akt, p-Erk1/2 and alters the expression of Bcl-2 family proteins. A, B: Western blot analysis of activation of p-Akt, p-Erk1/2 and expression level of Bcl-2, Bcl-xL, Bax and Bak1 in PNAM1 knockdown AsPC-1 and BxPC-3 cells. The photographs are representative immunoblots.