Table 1.
Genotype and allele frequencies of Notch polymorphisms in patients with IDC and DCIS and in controls
| Notch polymorphisms | Genotypes | No. of IDC/DCIS/UDH | IDC vs. UDH | DCIS vs. UDH | ||
|---|---|---|---|---|---|---|
|
|
|
|||||
| P | OR (95% CI) | P | OR (95% CI) | |||
| Notch1 (rs3124591) | CC | 0/0/0 | _ | _ | _ | _ |
| TC | 20/12/8 | 0.002 | 3.708 (1.534, 8.966) | 0.011 | 3.482 (1.283, 9.449) | |
| TT | 61/28/89 | 1 | 1 | |||
| CC + TC | 11/12/8 | 0.002 | 3.708 (1.534, 8.966) | 0.011 | 3.482 (1.283, 9.449) | |
| Allele | C | 20/12/8 | 0.566 | 0.798 (0.369, 1.727) | 0.002 | 4.103 (1.608, 10.469) |
| T | 142/68/186 | 1 | 1 | |||
| Notch2 (rs11249433) | CC | 0/0/0 | _ | _ | _ | _ |
| TC | 9/5/8 | 0.817 | 1.125 (1.414, 3.054) | 0.933 | 1.265 (0.390, 4.104) | |
| TT | 85/42/85 | 1 | 1 | |||
| CC + TC | 9/5/8 | 0.817 | 1.125 (1.414, 3.054) | 0.933 | 1.265 (0.390, 4.104) | |
| Allele | C | 9/5/8 | 0.821 | 1.119 (0.422, 2.965) | 0.935 | 1.250 (0.397, 3.932) |
| T | 179/89/178 | 1 | 1 | |||
| Notch3 (rs3815188) | AA | 15/6/14 | 0.803 | 0.879 (0.382, 2.104) | 0.524 | 0.701 (0.235, 2.093) |
| GA | 33/17/42 | 0.196 | 0.658 (0.348, 1.242) | 0.296 | 0.662 (0.306, 1.436) | |
| GG | 43/22/36 | 1 | 1 | |||
| AA + GA | 48/23/56 | 0.267 | 0.718 (0.399, 1.291) | 0.278 | 0.672 (0.327, 1.379) | |
| Allele | A | 63/29/70 | 0.495 | 0.862 (0.563, 1.321) | 0.315 | 0.762 (0.447, 1.297) |
| G | 119/61/14 | 1 | 1 | |||
| Notch3 (rs1043994) | AA | 3/1/1 | 0.582 | 3.227 (0.328, 31.80) | 0.532 | 2.219 (0.135, 36.60) |
| GA | 20/12/18 | 0.627 | 1.195 (0.582, 2.455) | 0.36 | 1.479 (0.638, 3.431) | |
| GG | 66/32/71 | 1 | 1 | |||
| AA + GA | 23/13/19 | 0.455 | 1.302 (0.651, 2.606) | 0.316 | 1.518 (0.669, 3.446) | |
| Allele | A | 26/14/20 | 0.323 | 1.368 (0.733, 2.553) | 0.299 | 1.474 (0.706, 3.075) |
| G | 152/76/160 | 1 | 1 | |||
| Notch4 (rs367398) | AA | 6/6/5 | 0.847 | 1.131 (0.324, 3.944) | 0.318 | 2.352 (0.653, 8.467) |
| GA | 38/17/36 | 0.986 | 0.995 (0.546, 1.812) | 0.84 | 0.926 (0.437, 1.962) | |
| GG | 52/25/49 | 1 | 1 | |||
| AA + GA | 44/23/41 | 0.97 | 1.011 (0.568, 1.801) | 0.791 | 1.100 (0.545, 2.219) | |
| Allele | A | 50/29/47 | 0.962 | 1.011 (0.637, 1.606) | 0.32 | 1.322 (0.762, 2.294) |
| G | 142/63/135 | 1 | 1 | |||
| Notch4 (rs520692) | GG | 0/0/2 | 0.234 | 1.030 (0.989, 1.074) | 0.543 | 1.030 (0.989, 1.074) |
| AG | 21/11/25 | 0.444 | 0.770 (0.394, 1.504) | 0.606 | 0.807 (0.356, 1.826) | |
| AA | 72/36/66 | 1 | 1 | |||
| GG + AG | 21/11/27 | 0.315 | 0.713 (0.368, 1.381) | 0.479 | 0.747 (0.332, 1.679) | |
| Allele | G | 21/11/29 | 0.224 | 0.689 (0.377, 1.259) | 0.38 | 0.717 (0.341, 1.509) |
| A | 165/83/157 | 1 | 1 | |||