Table 3.
Association of rs3124591 genotype and Notch1 protein expression with clinicopathologic features in patients with IDC
| Clinicopathological parameters | Notch1 genotype | P | Notch1 expression | P | ||
|---|---|---|---|---|---|---|
|
|
|
|||||
| TT (n) | TC (n) | High (n) | Low (n) | |||
| Age at diagnosis | ||||||
| < 51 years | 30 | 14 | 0.105 | 29 | 15 | 0.126 |
| > 51 years | 31 | 6 | 30 | 7 | ||
| Lymph node status | ||||||
| Positive | 31 | 11 | 0.745 | 35 | 7 | 0.028 |
| Negative | 30 | 9 | 24 | 15 | ||
| Tumor differentiation | ||||||
| Well & moderate | 53 | 12 | 0.022 | 47 | 18 | 1.000 |
| Poor | 8 | 8 | 12 | 4 | ||
| ER status | ||||||
| ER (-/+) | 28 | 13 | 0.138 | 28 | 13 | 0.352 |
| ER (2+/3+) | 33 | 7 | 31 | 9 | ||
| PgR status | ||||||
| PgR (-/+) | 33 | 13 | 0.393 | 35 | 11 | 0.451 |
| PgR (2+/3+) | 28 | 7 | 24 | 11 | ||
| HER-2 status | ||||||
| HER-2 (-/+) | 23 | 11 | 0.174 | 27 | 7 | 0.258 |
| HER-2 (2+/3+) | 38 | 9 | 32 | 15 | ||