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Diagnostic power of mutation-specifi c antibodies comparing with ARMS
| Mutation-specific antibodies | EGFR mutations | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|
| Anti-EGFR E746_A750 del | E746_A750 del | ||||
| score≥1 as positive | 100% | 100% | 100% | 100% | |
| score≥2 as positive | 41% | 100% | 100% | 77% | |
| score≥3 as positive | 53% | 91% | 75% | 79% | |
| Anti-EGFR L858R | L858R | ||||
| score≥1 as positive | 100% | 98.5% | 96% | 100% | |
| score≥2 as positive | 44% | 97% | 88% | 79% | |
| score≥3 as positive | 69% | 74% | 55% | 83% |
