Table 2.
Analysis of allelic association of rs3807989 with AF and CAD
| Phenotype (case/control) | Allele A frequency (case/control) | P-obs | OR (95% CI) | P-adj | P-emp |
|---|---|---|---|---|---|
| Total AF (839/1215) | 0.260/0.260 | 0.990 | 1.02 (0.85-1.22) | 0.828 | 0.905 |
| Lone AF (264/1215) | 0.268/0.260 | 0.738 | 0.99 (0.75-1.23) | 0.929 | 0.995 |
| Other AF (575/1215) | 0.266/0.260 | 0.688 | 1.06 (0.86-1.23) | 0.597 | 0.758 |
| AF with CAD (309/1215) | 0.297/0.260 | 0.306 | 1.30 (0.90-1.89) | 0.162 | 0.463 |
| AF w/o CAD (530/1215) | 0.262/0.260 | 0.970 | 0.97 (0.80-1.17) | 0.720 | 0.842 |
| AF with HT (265/1215) | 0.252/0.260 | 0.744 | 0.83 (0.61-1.11) | 0.206 | 0.627 |
| AF w/o HT (574/1215) | 0.274/0.260 | 0.379 | 1.06 (0.87-1.28) | 0.573 | 0.775 |
AF, atrial fi brillation; CAD, coronary artery disease; HT, hypertension; IS, ischemic stroke. P-obs: unadjusted P values; P-adj: obtained using multivariate logistic regression analysis. P-emp: obtained by performing 100,000 Monte-Carlo simulations.