Fig. 3.

Water ADC maps of representative treated groups obtained before therapy and at different times post-therapy

At 10 d after administration of sorafenib, a high-signal intensity was observed in the central part of the tumors on T2-weighted (T2W) images, suggesting necrosis in the central region of tumors (white arrow). At 14 d after administration, a significant increase in T2W images and ulceration of the tumor surface was found (white arrow)