Table 3.
Cytotoxicity and antioxidant effect of TTHL isolated product from ethnolic extract of C. leprosum in S. cerevisiae
| Yeast strains | ||||
|---|---|---|---|---|
| Treatment | WT | sod1Δ | sod2Δ | sod1Δsod2Δ |
| NCa | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 |
| TTHL 10 μg/mL | 100 ± 2.83 | 92.60 ± 2.83 | 83.20 ± 3.68** | 79.35 ± 2.19** |
| TTHL 50 μg/mL | 87.65 ± 5.16** | 89.30 ± 0.85** | 72.90 ± 7.07*** | 67.85 ± 10.54*** |
| TTHL 100 μg/mL | 79.45 ± 1.91*** | 75.65 ± 4.60*** | 62.25 ± 3.32*** | 58.15 ± 3.89*** |
| TTHL 500 μg/mL | 67.65 ± 3.04*** | 69.30 ± 3.68*** | 56.65 ± 1.06*** | 41.45 ± 4.03*** |
| PCb: H2O2 5 mM | 63.03 ± 4.12 | 16.27 ± 4.88 | 19.10 ± 4.03 | 19.33 ± 2.10 |
aNC: negative control (solvent-DMSO). Data significant in relation to negative control group (solvent) at *P < 0.05, **P < 0.01 and ***P < 0.001/ one-way ANOVA Tukey’s multiple comparison test. bPositive control (H2O2).