Table 1.
Ablative techniques.
Esophageal ablative technique | Method | Frequency of treatment | Complete eradication of intestinal metaplasia | Complete eradication of low grade dysplasia | Complete eradication of high grade dysplasia | Common complications (%) |
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RFA1 | Endoscopic balloon creates high frequency current which causes topical destruction of tissues | q2-3 months until resolution | 54–97% | 80–100% | 81–90% | Stricture (2–6%), hemorrhage |
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PDT2 | Photosensitizer given prior to procedure allows the application of a specific wavelength of light to cause creation of oxygen free radicals and topical destruction of tissues | 1-2 treatments, often followed by Nd:Yag laser therapy | 52% | 93% | 77% | Photosensitivity, Stricture (30%) |
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APC3 | Argon gas is passed through endoscope, monopolar current conducts through gas, and resulting heat causes topical destruction of tissues | q8 week treatments | 0–55% | — | 76% | Stricture (15%) |
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Cryotherapy4 | Topical application of coolants causes destruction of tissues | 3–5 treatments | 57–84% | 87% | 97% | Stricture (9%) |