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Two DnaB helicase-recruiting pathways for DNA replication restart at the stalled replication fork in vitro. The PriA-directed pathway (i.e., PriA-PriB-DnaT-DnaC-dependent reaction) preferentially uses fork structures without gaps in the leading strand, whereas the PriC-directed pathway (i.e., PriC-DnaC-dependent system) preferentially uses fork structures containing large gaps (>5 nucleotides) in the leading strand.
