Table 2.
Association between recipient and donor IL17A (n = 34) and IL-17F (n = 42) genotypes and occurrence of systemic cGVHD.
| Gene |
IL17A (G197A)
genotype |
n (%) | Systemic cGVHD | P* |
IL17F (7488T/C) genotype |
n (%) | Systemic cGVHD | P* | ||
|---|---|---|---|---|---|---|---|---|---|---|
| A | P | A | P | |||||||
| Recipient | GG | 12 (35.3%) |
9 | 3 | 0.03 | CC | 10 (23.8%) | 7 | 3 | NS |
| AG | 13 (38.2%) | 11 | 2 | CT | 18 (42.9%) | 9 | 9 | |||
| AA | 9 (26.5%) | 3 | 6 | TT | 14 (33.3%) | 10 | 4 | |||
|
| ||||||||||
| Donor | GG | 11 (32.4%) | 7 | 4 | NS | CC | 9 (21.4%) | 7 | 2 | NS |
| AG | 15 (44.1%) | 9 | 6 | CT | 19 (45.2%) | 12 | 7 | |||
| AA | 8 (23.5%) | 7 | 1 | TT | 14 (33.4%) | 7 | 7 | |||
A: absent; P: present; NS: not significant; ∗Chi-square test.