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. 2014 Jul 30;29(8):1138–1144. doi: 10.3346/jkms.2014.29.8.1138

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© 2014 The Korean Academy of Medical Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — GARS mutant proteins induce ERK activation in the spinal cord. (A) Western blotting revealed an increase in both pERK1 (p44 MAPK) and pERK2 (p42 MAPK) in the L5-spinal cord. FLAG was the adenovirus vector-expressing control. (B) Quantification of pERK1 and pERK2 levels in the L5-spinal cord; pERK1/2 levels were normalized to FLAG levels. ^*P < 0.001 compared to the WT, n = 4. (C) GARS mutants L129P and G240R induced a significant decrease in paw withdrawal threshold in virus-infected mice compared with Empt- and GATS-WT-expressing mice. Empt, empty virus without insert. n = 4.