[Table/Fig-1]:

Indication for use of multiple antibiotics [3]

Decreased toxicity without decreased efficacy

Synergy: 1 + 1 = 4 or more

Initial emergency treatment of seriously ill patients with no time to be wrong: "shotgun therapy"

To prevent and attack mutants bacteria- second antibiotic delays emergence of resistant bacteria, prolonging the effect of the active agents

Mixed infection with each microorganism requiring a different drug

To prevent super-infection by new bacteria

To attack nonsusceptible population

To reach otherwise unaccessible organisms;an uncommon but important consideration