| Outpatients with Comorbidities and Previous Antibiotic Therapy |
| Cephalosporin or β-lactam/β-lactamases inhibitor plus macrolide or Doxycycline or respiratory quinolone |
Preferred: Amoxicillin plus macrolide or amoxicillin-clavulanic acid or cephalosporin (I,II or III generation) plus macrolide Alternative: respiratory quinolone or respiratory quinolone plus benzylpenicillin |
Cephalosporin or β-lactam/β-lactamases inhibitor plus macrolide or a respiratory quinolone |
Cephalosporin (I,II or III generation) plus macrolide |
| Cap That Requires Hospitalization |
|
No risk for P. aeruginosa infection: Cephalosporin or β-lactam/β-lactamase inhibitor plus macrolide or a respiratory quinolone Risk for P. aeruginosa infection: Antipseudomonal β-lactam plus antipseudomonal quinolone or Antipseudomonal β-lactam plus aminoglycoside and macrolide or respiratory quinolone |
|
Cephalosporin or β-lactam/β-lactamase inhibitor plus macrolide or a respiratory quinolone |
No risk for P. aeruginosa infection: First choice: respiratory quinolone plus III generation cephalosporin or β-lactam/ β-lactamase inhibitor Second choice: Macrolide plus III generation cephalosporin or β-lactam/β-lactamase inhibitor Risk for P. aeruginosa infection: Antipseudomonal quinolone plus Antipseudomonal β-lactam/ Antipseudomonal β-lactam plus aminoglycoside and macrolide Antipseudomonal: β-lactam plus a quinolone and macrolide |
