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. 2014 Aug 12;5:299. doi: 10.3389/fphys.2014.00299

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Copyright © 2014 Merlot, Kalinowski and Richardson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representation of (A) normal and (B) tumor vasculature. Normal tissue is composed of mature, organized blood vessels, while tumor tissue consists of immature, leaky and tortuous vessels. The altered organization of tumor vasculature and disorganized lymphatic network results in vascular leakage and the accumulation of macromolecules (>40 kDa) within the interstitium and is known as the enhanced permeation and retention (EPR) effect. Adapted by permission from Macmillan Publishers Ltd: Nature Medicine (Jain, 2001), copyright (2001).