Table 1.

Localization of albumin-binding proteins and receptors.

Protein/Receptor	Tissue	Substrate
Albondin/gp60	Continuous endothelium	Native albumin
gp18	Endothelium, macrophages, fibroblasts and MDA-MB-453 breast cancer cell surfaces	Modified-albumin
gp30	Endothelium, macrophages, fibroblasts and MDA-MB-453 breast cancer cell surfaces	Modified-albumin
SPARC	Endothelial cells, vascular smooth muscle cells, skeletal muscle, fibroblasts, testicular, ovarian, pancreatic and a range of tumor cells	Native albumin
hnRNPs	Human tumor cell lines: CEM T-cell leukemia cells, MCF-7 breast cancer cells and MV3 melanoma cells	Native albumin
Calreticulin	Human tumor cell lines: CEM T-cell leukemia cells, MCF-7 breast cancer cells and MV3 melanoma cells	Native albumin
FcRn	Endothelium, antigen-presenting cells, gut, kidneys, lungs and the blood-brain-barrier (central nervous system endothelium and choroid plexus)	Native albumin
Cubilin	Kidney proximal tubule cells, absorptive intestinal cells, placenta, and visceral yolk-sac cells	Native albumin and probably modified-albumin
Megalin	Kidney proximal tubule cells, absorptive intestinal cells, placenta, visceral yolk-sac cells, choroid plexus, thyrocytes, ciliary epithelium, lungs, parathyroid, endometrium, oviduct, inner ear, and epididymal epithelial cells	Native albumin and probably modified-albumin