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. 2014 Aug 7;95(2):162–172. doi: 10.1016/j.ajhg.2014.07.002

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© 2014 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

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Plots of Stepwise Conditional Association of the HLA Amino Acid Polymorphisms and Classical HLA Alleles

(A–D) Stepwise analysis of HLA-C, HLA-B, HLA-A, and HLA-DQA1 in PsV-affected versus control individuals.

(E) Stepwise analysis of HLA-B in PsA-affected versus PsC-affected individuals. Each diamond represents the –log₁₀(p_omnibus) of the amino acid polymorphism encoded by the HLA gene. The colored horizontal line represents the –log₁₀(p_omnibus) of the most strongly associated classical allele of the HLA gene. The dotted horizontal line represents the significance threshold of p = 5.0 × 10⁻⁸. The most strongly associated amino acid polymorphisms and HLA classical alleles are labeled when their associations satisfied p < 5.0 × 10⁻⁸.