Figure 2.

The mutation rates of SpyCI⁺S. pyogenes genome and clinical strains. Strains harboring SpyCI integrated into mutL have phenotypes that range from non-mutator in Manfredo, where a novel CI promoter in the defective integrase gene rescues expression of mutL, to a hypermutator in M6 genome strain MGAS10394. Strain NZ131 does not carry a SpyCI and is presented as a wild type strain with regards to the MMR operon. The mutation rate is calculated as mutations per generation. The figure was drawn using the data from Scott et al. (2012).