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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Anesthesiology. 2014 Mar;120(3):683–693. doi: 10.1097/01.anes.0000435742.04859.e8

Table 2.

Parametric determinants of the increase in pulmonary [18F]fluorodeoxyglucose net uptake rate (Ki) of the smoke-exposed lung

k3 (min−1) Fe
Sheep # Control Smoke Control Smoke
Sheep s1 0.019 0.025 0.214 0.213
Sheep s2 0.010 0.012 0.157 0.188
Sheep s3 0.036 0.046 0.068 0.055
Sheep s4 0.020 0.024 0.097 0.086
Sheep s5 0.024 0.022 0.115 0.146
Mean 0.022 0.026 0.130 0.138
SD 0.009 0.013 0.057 0.067

Fe = distribution volume of the [18F]FDG-6-phosphate precursor pool, expressed as a fraction of lung volume; k3 = rate of phosphorylation of [18F]fluorodeoxyglucose ([18F]FDG) to [18F]FDG-6-phosphate by hexokinase. SD = standard deviation. The [18F]FDG net uptake rate is Ki = Fe · k3 (equation 3 in text). The increase of Ki in the smoke-exposed lung (fig. 3A) was associated with an increase of k3 in sheep s1 through s4, indicating increased phosphorylation of [18F]FDG by hexokinase. In sheep s5, the determinant of the Ki increase was an increase of Fe.