Table 1.

List of molecules investigated and their BBB permeability parameters

Compound	logBB	logPS	Calculated logPeff	BBB+/−	aPredicted BBB+/−	bPredicted logBB	References
Mannitol	−2.51	−4.30	−6.62	−	−	−2.30	(46,70,71)
Cimetidine	−1.42	−3.93	−3.94	−	−	−1.34	(20,43,72)
Salicylate	−1.10	−3.40	−5.17	−	−	−1.78	(29,45,73)
Salbutamol	−1.03	c	−1.95	−	−	−1.31	(43,74)
Atenolol	−0.87	c	−1.77	−	−	−0.57	(43,75)
Theophylline	−0.29	−2.80	−0.94	−	−	−0.27	(44,71,73)
Ibuprofen	−0.18	−1.58	−0.63	+	−	−0.16	(45,75,76)
Alprazolam	0.02	c	0.67	+	+	0.30	(43,75)
Nordazepam	0.50	−1.00	2.04	+	+	0.79	(43,77,78)
Imipramine	0.83	−1.43	2.13	+	+	0.82	(43,79,80)
Chlorpromazine	1.06	−1.20	2.68	+	+	1.02	(43,73,81)
Promazine	1.23	c	2.78	+	+	1.05	(43,82)

^aPredicted BBB+ if logP_eff ≥ 0, predicted BBB− if logP_eff < 0.

^bUsing Eq. 7.

^cNo data available.