Table 2.

Energy of hydrogen bonds in the LatB interface

α-α interactions				β-β interactions
TUB 1-α	TUB 2-α	Eaverage	SD	TUB 1-β	TUB 2-β	Eaverage	SD
Arg215	Glu90	–42.7	18	Arg308	Asp116	–44.8	20
Lys338	Asp127	–28.5	8	Glu290	Arg88	–38.9	12
Glu297	Arg121	–24.6	19	Arg308	Asp120	–36.7	14
Glu297	Lys124	–23.6	12	Lys299	Asp90	–32.6	12
Glu284	Ser54	–22.3	14	Asp297	Lys124	–22.3	19
Gln372	Glu55	–18.4	9	Tyr342	Asp120	–18.4	18
Tyr282	Ser48	–11.7	11	Ser280	Arg88	–16.6	16
His283	Phe49	–10.5	8	Lys338	Lys124	–14.8	10
				Lys338	Ser126	–12.0	11
Other bonds		–27.5	—	Other bonds		–14.8	—
Subunit energy		–210	35	Subunit energy		–252	65
Total energy						–462	70

The LatB interface refers to two αβ-tubulin heterodimers (TUB 1 and TUB 2) aligned laterally in the B-configuration. Average energy and standard deviation (SD) values are taken from eight different representative snapshots. Energies are expressed in kJ/mol.