Table 3.

Energy of hydrogen bonds in the LatA interface

α-β interactions				β-α interactions
TUB-α	TUB 2-β	Eaverage	SD	TUB 1-β	TUB 3-α	Eaverage	SD
Asp47	Arg284	–42.2	15	Arg88	Glu279	–35.2	15
Lys124	Asp297	–31.7	9	Lys124	Glu284	–27.0	12
Gln85	Ser280	–23.6	10	Ile86	Tyr282	–23.0	12
Asp46	Arg278	–23.0	13	Asp90	Lys280	–18.6	15
Asp127	Asn334	–22.6	5	Asn54	Glu284	–14.4	13
Asp120	Lys338	–22.4	14	Glu127	Thr334	–13.8	18
Gln128	Gln293	–18.6	12	Asp90	Ala281	–12.9	11
Asp47	Gln282	–16.5	14	Glu127	Thr337	−10.3	14
Glu55	Arg284	–14.8	18
Arg121	Asp297	–13.1	24
Asp47	Arg278	–11.9	13
Other bonds		–58.2	—	Other bonds		–17.8	—
Subunit energy		–299	23	Subunit energy		–173	44
Total energy						–472	46

The LatA interface refers to one αβ-tubulin heterodimer (TUB 1) aligned laterally in the A-configuration with an α-and β-subunit (TUB 2β and TUB 3α). Energies are expressed in kJ/mol.