Table 1.

Drugs that may lower serum levels of targeted therapies

Erlotinib/gefitinib	Afatinib
Rifampin, rifabutin, rifapentine, phenytoin, phenobarbital, carbamazepine, St. John’s wort, proton pump inhibitors, H2-blockers, antacids, tobacco	Rifampin, phenytoin, carbamazepine, St. John’s wort, primidone, tipranavir