Table 1.
Expression and prognostic significance of C4.4A in pulmonary squamous cell carcinoma and adenocarcinoma
| C4.4A reactivity | Multivariate survival analysis4 | Ref. | ||||||
| Premalignant lesions | 01 | + | ++ | +++ | [34] | |||
| SCC | Normal | 100% | Not available | |||||
| Hyperplasia | 59% | 41% | ||||||
| Metaplasia | 29% | 71% | ||||||
| Dysplasia | 20% | 80% | ||||||
| AC | Normal | 100% | ||||||
| AAH | 17% | 37% | 37% | 10% | ||||
| Invasive cancer | Median2 | Range | Lower quartile | Upper quartile | HR (95%CI) | P-value | [33] | |
| SCC | 8 | 0-16 | 5 | 10 | 0.82 | |||
| AC | 13 | 0-16 | 0 | 6 | 1.65 (1.24-2.19) | 0.0005 | ||
1
0: Negative; +: Weakly/focally positive; ++: Positive; +++: Strongly positive;
2
Refers to product of C4.4A intensity (0-4, where 0 = negative, 1 = very weak, 2 = weak, 3 = moderate and 4 = strong staining) and frequency (0-4, where 0 = 0%, 1 = 0%-25%, 2 = 26%-50%, 3 = 51%-75% and 4 ≥ 76% positive tumor cells);
3
Median value for non-solid and solid AC is 0 and 4, respectively;
4
Performed by the Cox proportional hazards model. SCC: Squamous cell carcinoma; AC: Adenocarcinoma.