Table III.

SNPs associated with haemolytic score.

Variant information							Meta- analysis			CSSCD
SNP	Chr	Gene	bp	Coded allele	Non- coded allele	MAF	β	SE	P-value	β	SE	P-value
rs7203560	16	NPRL3	184390	C	A	0·07	−0·44	0·07	2·06 × 10−09	−0·44	0·09	6·04 × 10−07
rs7948471	11	OR51I2,OR51I1	5471746	A	G	0·21	−0·26	0·04	3·03 × 10−10	−0·21	0·05	5·87 × 10−05
rs7938426	11	OR51I2,OR51I1	5471832	G	A	0·21	−0·25	0·04	1·09 × 10−08	−0·21	0·05	6·08 × 10−05
rs2445284	11	OR51L1	5029703	G	A	0·05	−0·82	0·07	1·34 × 10−29	−0·42	0·10	7·39 × 10−05

Variant information							Walk-PHaSST			PUSH			London
SNP	Chr	Gene	bp	Coded allele	Non- coded allele	MAF	β	SE	P-value	β	SE	P-value	β	SE	P-value
rs7203560	16	NPRL3	184390	C	A	0·07	−0·53	0·22	0·014	−0·13	0·31	0·672	−0·42	0·20	0·0367
rs7948471	11	OR51I2, OR51I1	5471746	A	G	0·21	−0·35	0·11	0·002	−0·39	0·14	0·004	−0·46	0·15	0·017
rs7938426	11	OR51I2, OR51I1	5471832	G	A	0·21	−0·37	0·11	0·0012	−0·39	0·14	0·004	NA	NA	NA
rs2445284	11	OR51L1	5029703	G	A	0·05	−1·32	0·15	1·60 × 10−17	−1·75	0·17	3·01 × 10−21	0·41	0·28	0·146

Single nucleotide polymorphisms (SNPs) meeting significance threshold (5 × 10⁰⁴) in the CSSCD study that replicate in the three independent cohorts. The table reports the SNP identifier from dbSNP, chromosome (Chr), physical coordinates [human genome (hg)19], the coded allele in PLINK (also minor allele) and the non-coded allele, the minor allele frequency (MAF), the gene clusters where the SNP is located, and regression coefficient (β), standard error (SE) and P-value in each study. Additive models of association were used in all studies adjusting for age and gender, bp denotes position of the SNP according to hgl9 coordinates.