Figure 2.

Pathway and process analyses of genes differentially regulated in the spleen of Ity, Ity3, Ity3.RecG, and Ity3.RecN mice during infection. Gene ontology classifications generated by clustering the genes that are differentially regulated in each strain upon infection. (A) Gene ontology (GO) molecular pathways and (B) Gene ontology (GO) processes (C) pathways (D) Process networks that are enriched in the four mouse strains. The sub-congenic strain Ity3.RecG shows a lower −log(p-value) for chemokine and cytokine receptor activity within the GO molecular pathways as well as lower −log(p-values) for response to bacteria in the GO processes. This is consistent with previous data suggesting that the Ity3.RecG mice have a diminished inflammatory response following infection compared to parental strains (16).