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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Brain Res. 2014 Mar 11;1560:73–82. doi: 10.1016/j.brainres.2014.02.049

Figure 4. DAPT administration significantly reduces Aβ40 after SCI.

Figure 4

DAPT (a γ-secretase Inhibitor) and vehicle were administered orally (30mg/kg) twice a day for 3 days to sham and injured mice starting at 15 minutes after injury. Mice were sacrificed (n=4) on the next day after the last dose and Aβ40 ELISA was performed. There is no difference between the amount of Aβ present in sham vehicle- and DAPT-treated. However, the DAPT-treated injured mice have significantly (p value < 0.01) less Aβ than the vehicle-treated SCI mice.