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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Brain Res. 2014 Mar 11;1560:73–82. doi: 10.1016/j.brainres.2014.02.049

Figure 6. Genetic ablation of Bace1 reduces functional recovery after SCI in mice as measured by behavioral testing.

Figure 6

Wild type (WT, n=6) and Bace1 knockout (Bace1 KO, n=7) mice were injured and evaluated using BMS and BLG scores at 1 day post-injury (DPI) and weekly thereafter. A. Naïve WT and Bace1 KO mice sacrificed and sections were stained with Eriochrome cyanine R. B. WT mice have significant (p value < 0.01 at 28 days) higher BMS score 14 days after injury as compared to Bace1 KO mice. C. The mice were also evaluated based on their stepping using the BLG score. A significant (p value < 0.01 at 28 days) improved performance in WT mice is observed as early as 14 DPI. D. Sections from spinal cord were processed for Eriochrome cyanine R staining and analyzed using sterological techniques. The white matter spared in the WT mice is significantly (p value = 0.0263) higher than the Bace1 KO mice. E. Representative images show higher staining present in the WT as compared to Bace1 KO mice at the epicenter (Mag. Bar = 500 µm).