Table I.

Criteria for Sepsis Syndrome

Screening Criteria	Confirmatory Criteria
Presence of either (1) or (2):	Presence of any 1 of the following, without an alternative explanation:
1. All 4 of the following:	1. PaO2/FiO2 < 280 (intubated) or when using a 40% face mask (not intubated)
Rectal temperature >38.3°C or <35.6°C	2. Arterial pH < 7.30
Respiratory rate of >20/min or mechanical ventilation	3. Urine output < 30 ml/hour
Heart rate > 90 beats/min	4. Systolic blood pressure < 90 mm Hg or fall in systolic blood pressure > 40 mm Hg sustained for 2 hours despite fluid challenge
Clinical evidence of infection	5. Systemic vascular resistance < 800 dynes.s.cm2
2. One or more blood cultures positive for a pathogen at 48 hours after the onset of sepsis	6. Prothrombin time or partial thromboplastin time greater than normal or platelets > 100×106/l or platelets decreased to <50% of most recent measurement before current day
	7. Deterioration in mental status within 24 hours