Table 2.
Studies Incorporating Use of FSIGT or EHC Methodologies to Determine Effect of Resistance Training on Insulin Sensitivity
| Study | Subject population | Design | Testing | Major findings | Hour after last bout |
|---|---|---|---|---|---|
| Zachwieja et al. (721) | 64–75 years M | 4×/wk, 16 weeks 4×4–10, 75–90% 1 RM |
FSIGT | 33% ⇑ in insulin sensitivity | 168 |
| Ibanez et al. (302) | 66±3 years M, T2D | 2×/wk, 16 weeks 50–70% 1 RM, then 70–80% 1 RM, 10–15 repetitions |
FSIGT | 25% ⇑ in insulin sensitivity, ⇓ fasting glucose | 24 |
| Shaibi et al. (586) | 15±0.5 years M Hispanic | 2×/wk, 16weeks Progressive increase in workload |
FSIGT | 45% ⇑ in insulin sensitivity | 48–72 |
| Van Der Heijden et al. (659) | 15±0.5 years M/F Hispanic | 2×/wk, 12weeks Progressive increase in workload |
FSIGT (plus tracer) | ⇑ peripheral in 8 of 12 subjects, but ⇓ in 4 of 12; hepatic insulin sensitivity ⇑ 24% | 72 |
| Miller et al. (440) | 58±1 years M | 1 set 90% 1 RM for three repetitions ⇓ load up to 15 repetitions 3×/wk, 16 weeks |
EHC OGTT |
24% ⇑ glucose infusion w/EHC ⇓ insulin during OGTT, fasting insulin ⇔ glucose during OGTT |
22–24 |
| Ryan et al. (558) | 58±2 years F | 3×/wk, ~16 weeks 1–2 sets 15 repetitions |
EHC | 16% ⇓ in insulin response | 24 |
| Ishii et al. (308) | 47±9 (SD) years, T2D | 5×/wk, 4–6 weeks 2×10–20 repetitions 40–50% of 1 RM |
EHC | 48% ⇑ in glucose disposal | 48 |
| Poehlman et al. (506) | 28±3 years F | 3×/wk, 6 months 80% 1 RM |
EHC | 9% ⇑ in glucose infusion | 96±24 |
| Holten et al. (276) | 61±2 years, healthy and T2D | 3×/wk, 6 weeks, 1 legged training, 8–12 repetitions | EHC | ~10% ⇑ in leg glucose clearance | 16 |
| Ryan et al. (557) | 69±1 years M/F | 3×/wk, 6 months 1–2 sets, 8–15 repetitions |
EHC | Nonsignificant ⇑ in SI | 24–36 |
| Andersen et al. (20) | 26±1 years M | RT cessation for 90 d, RT was 3×/wk, 3 months Periodized workload |
EHC | 11% ⇓ in insulin sensitivity | – |
| Reynolds et al. (536) | 67±2 years M/F | 3×/wk, 16 weeks 2×10–12 repetitions |
EHC | 15% ⇑ in glucose disposal ⇔ insulin response, fasting insulin |
24 |
| Klimcakova et al. (359) | 50±2 M | 3×/wk, 3 months 1×12–15 repetitions |
EHC | 24% ⇑ glucose disposal | 48–72 |
| Davidson et al. (143) | 60±4 | 3×/wk, 1 set up to 15 reps (20 min/session) | EHC | nonsignificant ⇑ in SI | 36–48 |