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. Author manuscript; available in PMC: 2014 Aug 12.
Published in final edited form as: Nat Chem Biol. 2010 Dec 26;7(2):101–105. doi: 10.1038/nchembio.499

Figure 2.

Figure 2

Proline biosynthetic pathway in E. coli. The enzyme ProB converts glutamate to γ-glutamyl phosphate which is then reduced to glutamic acid 5-semialdehyde by ProA. Glutamic acid 5-semialdehyde spontaneously rearranges to form Δ1-Pyrroline 5-carboxylate which is converted by ProC, to proline, a known inhibitor of ProB.