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De novo pathway for GSH biosynthesis. The combined effect of ProB(supp) (higher IC50 for l-Pro) and ProA(supp) (loss of function) leads to accumulation of γ-glutamyl phosphate which reacts with free cysteine or homocysteine in the cell to form γ-glutamyl cysteine or γ-glutamyl homocysteine. The enzyme GshB adds glycine to γ-glutamyl cysteine to form GSH.
