Table 3.
Hip circumference and breast cancer risk in Nigerian women, 1998–2009
| Cases | Controls | Age-adjusted OR (95% CI) | Adjusted OR (95% CI)† | Adjusted OR (95% CI)‡ | |
|---|---|---|---|---|---|
| Total | |||||
| 54–92 cm | 312 | 282 | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) |
| 93–99 cm | 266 | 286 | 0.67 (0.52–0.86) | 0.64 (0.49–0.83) | 0.53 (0.40–0.70) |
| 100–107 cm | 283 | 251 | 0.73 (0.57–0.94) | 0.62 (0.47–0.82) | 0.44 (0.32–0.62) |
| 108–157 cm | 361 | 279 | 0.76 (0.59–0.97) | 0.62 (0.48–0.82) | 0.36 (0.24–0.55) |
| P for trend | 0.10 | 0.003 | <0.001 | ||
| Mean ± SD | 101.3±13.0 | 100.2±11.6 | |||
| Per 10 cm | 0.95 (0.88–1.02) | 0.90 (0.83–0.97) | 0.72 (0.63–0.83) | ||
|
| |||||
| Premenopausal | |||||
| 54–92 cm | 185 | 224 | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) |
| 93–99 cm | 153 | 231 | 0.60 (0.44–0.81) | 0.53 (0.38–0.74) | 0.44 (0.31–0.63) |
| 100–107 cm | 161 | 185 | 0.70 (0.52–0.96) | 0.57 (0.41–0.81) | 0.41 (0.28–0.60) |
| 108–157 cm | 205 | 180 | 0.83 (0.61–1.13) | 0.61 (0.43–0.85) | 0.35 (0.22–0.56) |
| P for trend | 0.61 | 0.02 | <0.001 | ||
| Mean ± SD | 101.0±12.8 | 99.0 ± 11.2 | |||
| Per 10 cm | 0.99 (0.91–1.09) | 0.91 (0.82–1.00) | 0.73 (0.63–0.85) | ||
|
| |||||
| Postmenopausal | |||||
| 54–92 cm | 127 | 58 | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) |
| 93–99 cm | 113 | 55 | 0.88 (0.56–1.38) | 0.93 (0.58–1.49) | 0.76 (0.47–1.23) |
| 100–107 cm | 122 | 66 | 0.79 (0.51–1.23) | 0.74 (0.47–1.18) | 0.52 (0.31–0.85) |
| 108–157 cm | 156 | 99 | 0.68 (0.45–1.01) | 0.69 (0.44–1.06) | 0.38 (0.22–0.66) |
| P for trend | 0.05 | 0.06 | <0.001 | ||
| Mean ± SD | 101.7±13.2 | 103.6±12.1 | |||
| Per 10 cm | 0.88 (0.78–0.98) | 0.88 (0.78–0.99) | 0.71 (0.59–0.84) | ||
|
| |||||
| P for interaction* | 0.20 | 0.98 | 0.92 | ||
Abbreviations: OR, odds ratio; CI, confidence interval; SD, standard deviation
Interaction between hip circumference and menopausal status
Adjusted for age at diagnosis or interview (categorical), ethnicity, education (categorical), age at menarche (continuous), number of live birth (categorical), age at first live birth (continuous), duration of breastfeeding (categorical), menopausal status, family history of breast cancer, benign breast disease, hormonal contraceptive use, alcohol drinking, and height (continuous).
Adjusted for body mass index (continuous) and waist circumference (continuous) in addition to the above variables.
Categories of hip circumferences are based on quartiles in controls.