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. Author manuscript; available in PMC: 2014 Aug 12.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Sep 3;257(1):102–110. doi: 10.1016/j.taap.2011.08.024

Figure 3. Hemodynamic Function Measurements Indicate p21KO Mice Were Resistant to Dox.

Figure 3

Mice at the end of 10 weeks of Dox treatment were used to measure hemodynamic function using a Millar 1.4 Fr catheter system. Representative pressure-volume loops were shown for one animal from each group (A). Preload Recruitable Stroke Work (PRSW, B), End Diastolic Pressure-Volume Relationship (EDPVR, C) and End Systolic Pressure-Volume Relationship (ESPVR, D) were obtained by decreasing the preload during transient Inferior Vena Cava occlusion from WT control (n=6), WT treated with Dox (n=6), p21KO control (n=6), and p21KO treated with Dox (n=6). An asterisk indicates significance difference (p<0.05) between the means of treated group versus control.