Table 1.

VITAH trial inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
• Age ≥ 18 years	• Any major cardiovascular event within the last 6 months prior to enrolment (this includes, but is not limited to, new onset arrhythmia, hospitalization for a cardiovascular complication)
• Thrice weekly hemodialysis outpatient within the Southern Alberta Renal Program
• Physician consent to participate	• Refusal to cease vitamin D therapy for four (4) weeks prior to initiation of the study
• Ability and agreement to cease any prior vitamin D medication for four (4) weeks prior to initiation of the study	• Palliative status or metastatic malignancy
• Ability to comprehend study protocol and provide oral and written consent in English (native language or translated)	• Known or anticipated upcoming change in dialysis modality including transfer to peritoneal dialysis, kidney transplant, or change in current hemodialysis schedule/duration